Saturday, October 1, 2011

Last week, Nature Genetics carried twin studies into the genetics of bipolar disorder and schizophrenia. This special report examines the month’s research into the illnesses in detail, with Wikinews obtaining comment from experts based in Australia, the United States, and the United Kingdom ahead of the U.S. Mental Illness Awareness Week, which starts tomorrow.

Eleven genetic regions were identified; seven of these were for schizophrenia and five of those were hitherto undiscovered. The parallel studies, conducted separately, examined more than 50,000 people worldwide and identified two genetic loci associated with both diseases.

Little is known about the two illnesses, each of which affects around 1% of people and is treated with strong medication. Bipolar sufferers experience extremes of mood – depression and mania, hence the previous name “manic depression” for the illness. Schizophrenia is associated with hearing voices, chaotic thoughts, and paranoia. There is no known cure.

The latest research examined both the healthy and the afflicted, using computers to scan genomes. Inheritance was thought to be a factor from prior knowledge of the diseases as a familial trait, but the original desire had been to isolate a single faulty gene. Instead it has become apparent that the genetic factors are many; in the case of schizophrenia, at most around 30% of the genetic components are thought to have been identified.

The University of Chicago’s Pablo Gejman, a lead researcher on the schizophrenia study, explained to Wikinews in a telephone interview from Buenos Aires, Argentina that “One of the goals of genetic research is to find druggable targets” – to “find treatments at the root of the problem”.

Whilst noting that there is no guarantee the genetic code identified is druggable, Gejman named calcium-activated neurochemical channels in the brain as candidates for new drugs. The channels were linked to schizophrenia in the study.

Gejman explained that a genetic locus called mir137 “suggests an abnormality of gene regulation.” The diseases are so poorly understood that it is uncertain if they are in fact two components of a single spectrum, or even each comprised of multiple illnesses.

The new and “provocative data” gathered showed the significant loci identified were “not part of the pre-existent hypothesis.” Calling this “interesting”, Gejman added that the team found no evidence that dopamine receptors are involved; current drug treatments target dopamine receptors. The findings are “not related to anything we thought we knew [about schizophrenia],” he told our correspondent.

Quizzed about the possibility variations in the genetic factors involved in expressing the diseases explained the variation seen in symptoms, Gejman was uncertain. “We will have the answer, probably, only when we sequence the whole [human] genome.” He notes that the relationship between genotype and phenotype is unclear, and that “We know very little of the genetic architecture of schizophrenia and” other disorders.At the time the results were published, participating scientist Professor Rodney Scott from the University of Newcastle in Australia said “The strength of this research is in the numbers. The findings are robust and give us a lot of statistical power to identify the genetic determinants of schizophrenia.” Scott told Wikinews that “If any single centre tried to undertake such a study, it would require millions of pounds. Since it was a collection of data from across the world the costs were spread. In this era of financial difficulty it will become increasingly difficult to secure funding for this type of project even though the pay-offs will be significant.”

Gejman expressed similar sentiment. “The research budget is not growing, which makes [funding] difficult,” he said, though he felt the cost “is not prohibitive because of the benefits.” “I think that it was money well invested” and “very well spent for the future,” he said, adding that organisations in Europe and the US were aware of the importance of such research.

Gejman also agreed on reliability – the study is “Very reliable because of the sample size; that should provide robust results… [we] have worked with a much larger sample than before.” Scott told us it was “a highly reliable study” that has the potential to lead to new treatments “in the long run”.

Another point was the two genetic loci identified as common to both – how much support do they lend to the notion the diseases are linked? “Until more information is available it is really only suggestive,” says Scott. “Strong enough to say there may be potentially a common pathway that bifurcates to give rise to two diseases.”

“It is an excellent demonstration,” said Gejman “because you have the same chains that are common to both disorders, in fact not just the same chains but also the same alleles.” He stressed uncertainty in how strong the relationship was, however.

Scott said examining how the variation of genetic factors may translate into varied symptoms being expressed “certainly is a good target for future research”; “It is not known how many genetic factors contribute to either of these diseases but it is likely that not all are necessary to trigger disease.” “New questions will always arise from any major study,” he told our reporter. “Certainly, new questions about bipolar and schizophrenia are now able to be formulated on the basis of the results presented in the two reports.”

These weren’t the only studies to look at the two diseases together in September. The British Medical Journal carried research by a team from the University of Oxford and King’s College London that examined mortality rates in England for schizophrenia and bipolar sufferers. They found both groups continued to suffer higher mortality rates than the general population – whilst these included suicides, three quarters of deaths were down to ailments such a s heart conditions. General death rates dropped from 1999 to 2006, but sufferers below 65 saw their death rate remain stable – and the over-65 saw theirs increase.

“By 2006, the excess risk in these groups had risk to twice the rate of the general population, whereas prior to that it had only been 1.6 times the risk, so it increased by almost 40%,” said Dr Uy Hoang of Oxford. The study looked at every discharged inpatient with a diagnosis of either condition in England in the relevant time.

Hoang said at the time of the research’s release that doctors should devote attention to predicting and preventing physical illness associated with mental disorders. His study comes at a time when the UK has launched a “no health without mental health” strategy which does attempt to screen for physical illnesses coinciding with mental illnesses. The government aims to reduce the death rate of those with mental disorders.

Rodney Scott described this research result to Wikinews as “Possibly” connected to genetic association with other hereditary ailments, such as cardiovascular disease; he told us another possibility is that “The continued raised mortality rates may be associated with the diseases themselves.”

“We believe the NHS [National Health Service] and Department of Health need to do more to support research and service development for people with bipolar disorder,” Wikinews was told by Suzanne Hudson, Chief Executive of London-based British charity MDF The Bipolar Organisation. “The provision of specialist services for bipolar is very limited in the UK and the demand for our services is unprecedented.”

“A genetic test for bipolar would be a useful tool but the science and ethics are very complex,” Hudson told us, referring to the Nature Genetics genetic study. “Just because someone has ‘bipolar genes’ does not mean they might go on to develop it. Family studies of bipolar show that this is a likely outcome of genetics research in this area. Even if it were possible to accurately predict bipolar in this way, questions about how you treat that person are difficult. For example do you start medication that is not necessary at that point in time?”

“Current treatment is not satisfactory” because it does not always work and has “side effects,” Gejman told us. Robert Whitaker, a US medical journalist and book author, told an audience in New Zealand at the end of August that evidence suggests antidepressant drugs may make children and teenagers worse – “You see many become worse and end up with a more severe diagnosis, like bipolar illness,” and the suicide risk may increase.

Whitaker blames commercial interests. “The adult market appeared saturated, and so they began eying children and teenagers. Prior to this, few children and youth were seen as suffering from major depression, and so few were prescribed anti-depressants.”

One possible alternative, raised by a connection between depressive illness and inflammation, is aspirin and similar compounds. “The link between inflammation and mood disorders has been known for sometime and the use of aspirin and other drugs in depression is now becoming more common in the literature,” Hudson says. “Any new treatments for bipolar, which is a very complex and co-morbid illness, has to be a good thing.”

Professor Dr. Michael Berk, chairman of psychiatry at Australia’s Deakin University, recently gave a talk to just this effect. Speaking at this year’s Congress of the European College of Neuropsychopharmacology, held this past month, he also highlighted statins as a treatment. Recognising the link to physical ailments, he told an interviewer “The brain does not exist in isolation, and we need to understand that pathways similar to those that underpin risks for cardiovascular disorders, stroke, and osteoporosis might also underpin the risk for psychiatric disorders, and that other treatments might be helpful.”

Berk also touched upon speed of diagnosis and treatment; “Early interventions can potentially improve the outcome” of bipolar sufferers, he told his audience. MDF The Bipolar Organisation claim an average of ten years is possible before a person is diagnosed. “This clearly is an issue, if we believe that earlier diagnosis and treatment facilitate better outcomes,” Berk told Wikinews. Though he questions the effectiveness of currently-used drugs on advanced bipolar cases, he does not go so far as to say drugs are actively harmful. He told us “it appears that our best treatments work best earlier in the illness course; and that seems to apply to psychotherapy and pharmacotherapy.”

Berk has already performed research using statins which suggests they can form a treatment. He now seeks funding for research involving aspirin. On funding, he tells Wikinews “psychiatric disorders comprise between 16% and 22% of the burden of disability (depending on who measures it), attracts^[sic] just over 6% of the clinical budget at least in Australia and 3% of the research budget. Research as a discretionary spending item is at great risk.”

Berk’s research, in the past, has been funded by companies including GlaxoSmithKline. Hudson told Wikinews this did not concern her charity; in fact, they welcomed it. “We believe it is important pharmaceutical companies continue to invest in the development of new medications for bipolar. This is how it works in all other health specialities and mental health should be no different.”

“There is a need for greater education for mental health professionals and GPs [general practitioners] about bipolar [in the UK],” she told us. “As the national bipolar charity we receive many, many calls and requests from GPs and other health professionals for our leaflets and information sheets which is fantastic. We very much welcome opportunities to work together for the benefit of individuals affected by bipolar.”

Wikinews contacted the UK’s National Institute for Clinical Excellence (NICE) to discuss issues raised in this article, including future treatments, genetic screening, and mortality rates. NICE did not respond.

Might statins and/or aspirin improve treatment – might they be cheaper, perhaps, or safer? “This is an area of research promise,” says Berk, “however it is too early to make any clinical treatment claims; [all] we can say is that this needs to be studied in properly designed trials capable of giving a more definitive answer.” And what of possible explanations for the increased mortality rate observed in England? Should researchers look at whether bipolar influences more than just the brain, or if it is linked to other genetic conditions?

“For sure,” he told us. “There is new evidence that similar pathways contribute to the risk for both medical and psychiatric illness, both in terms of lifestyle factors, and biomarkers of risk.”

Saturday, April 23, 2005Queensland Australia’s Sir Joh Bjelke Petersen, a controversial figure who served as the State’s Premier for 19 years and reigned over the government that later became the subject of the Fitzgerald Inquiry, has died in hospital at Kingaroy, aged 94.

“By any measurement, Sir Joh was an exceptional state builder who will be remembered for consistently placing Queensland first,” said the Australian Governor General, Major General Jeffery, in a statement.

Australian Prime Minister, John Howard: “He was certainly a strong political figure and I extend my condolences to his wife and his family.”

But not all voices were sympathetic, prominent Queensland Aboriginal activist Sam Watson for example: “Aboriginal people will always remember him as a racist, a thug and a dictator.”

Having suffered severe ill-health for some weeks, and declining health for years, Sir Joh passed away at around 6pm AEST. He was surrounded by his family, who had been summoned yesterday by Lady Flo, his wife and one-time Senator, for final goodbyes.

Phrases such as “Don’t you worry about that” and “Goodness gracious me” were like trademarks to the maverick leader.

Known simply as ‘Joh’ to many, he would famously describe press conferences as ‘feeding the chooks’. Today Kingaroy locals taunted waiting press with cries from “You’re chooks, you’re chooks, ha ha” to “Go home, ya vultures”, and some obscenities, reported the Courier-Mail of Brisbane.

His fall from power at the end of the 80s was surrounded in controversy, with the state embroiled in corruption findings going to the level of his deputies, and Bjelke Petersen’s claims of ignorance coming under challenge with charges of perjury. The case was never heard due to a controversial hung jury: the foreman of the jury, Luke Shaw, had been an office-bearer of the Young Nationals — an arm of Bjelke Petersen’s National Party — as well as a member of a group calling themselves ‘Friends of Joh’.

Having had his start in life as a peanut farmer in remote Kingaroy, the former Premier was fit up until the very end, but palsy was paralyzing his muscles and organs, to which he eventually succumbed.

“Throughout his life Sir Joh combined enormous energy, vision and an immense capacity for hard work, most especially during his 19-year term as Premier of Queensland,” the Governor General said.

“What looked to us to be huge risks at the time turned out to be nation building,” said Bob Katter, a former minister of Joh’s Government, who credited Sir Joh with starting the Queensland coal, aluminum and tourism industries.

He is also remembered for dismantling many of the State’s unions, and for a somewhat totalitarian and heavy handed style of keeping control.

Under Joh, street protests were banned and Special Branch monitored extensively those the authoritarian leader saw as subversives, measures prompting Queenslander, Australian Civil Liberties Council, Terry O’Gorman, to comment Sir Joh was “the most appalling premier Queensland has ever had in terms of civil liberties and human rights”.

Joh was also influential in the famous case of the Dismissal by the Governor General of then-Prime Minister Gough Whitlam, in 1975.

In his last years as Premier, he had taken his cause to the nation’s capital, with the “Joh for PM” campaign. But this distraction has been credited with the downfall of his government, with corruption investigations at last being conducted by his stand-in, Bill Gunn.

The body of Sir Joh, who was of Lutheran faith, is to be buried at Bethany, the family property near Kingaroy.

Unsolicited quotes from ordinary Australians, many ex-Queenslanders seeking refuge in southern states, on hearing the news:

“Outrageous bastard! Oh God! That was polite!” — “Karen”

“Guilty as Hell. And that’s where he is now.” — “Michael”

“Yay! Good riddence to bad rubbish” — “Liza”

“The dictator is gone our time 2 sing” — “John. H.”

“Yeah he took a while — about 90 f*cking years overdue!” — “Hose Man”

“The pope an joh at least somethin going right” — “Helen”

“Corrupt f*cking sh*teating Bible-bashing f*ckw*t is dead. And thank f*ck. I haven’t been so happy since September 11!” — “Greg”

“I don’t drink but I’ll be having a red whilst dancing on his grave.” — “Cellest”

“Ding dong the d*ck is dead!” — anon.

“Yeahhh!!! Fucking finally” — “Leo”

“It’s a great day today the Rednecks are silent a great victory has been won” — “Zenner”

Sunday, April 29, 2012

As many states across the US continue to struggle financially, many individuals, including some economists report multiple positive indicators for Texas.

The chief economist with Comerica Bank told media sources this week that most of the improvements are attributed to strong creations of jobs in both the energy and manufacturing and services sectors. More specifically, that report called the state’s recent job growth, “robust”.The state’s unemployment rate in March was more than 1% lower than the nationwide rate, according to recent data.

When asked her opinion about the state’s present economic trajectory, Chantal Woodhull, a middle school teacher in Tyler, Texas told Wikinews, “It’s getting better.” Other sources indicate slight improvements in the real estate sector.

According to a recent report, retail job growth in Houston outstretched all other states, increasing its number of workers by over 4%. Across the US, retail jobs are improving at a slow pace in many large metropolitan areas.

Tuesday, October 4, 2005

Reliant Energy and CenterPoint Energy–two local utilities in Houston, Texas–plan to increase consumer rates in response to increased demand and recent disasters.

Reliant Energy is expected to raise rates to effect a 14% increase on a 1,000 kilowatt-hour bill. A typical customer could see an increase up to $20 per month. Reliant has reached an agreement with the Texas Public Utilities Commission to raise rates in two steps, once at the end of October, and again on 1 January 2006.

CenterPoint Energy must increase charges for services such as meter-reading and customer service. The Texas Public Utilities Commission prohibits natural gas companies from buying wholesale product, raising rates, and reselling. Wholesale prices of natural gas also continue to rise due to increased demand and declining domestic supply. Natural gas cannot be easily shipped to other regions like oil.

Consumer energy prices are expected to rise across the state, in some cases as much as 20%.

The Texas Public Utilities Commission must approve rate increases before they go into effect, but approval is expected.

Friday, September 14, 2007

Reports say that O.J. Simpson, a former American football player is a suspect in a robbery that took place on Thursday night at the Palace Station Hotel and Casino in Las Vegas, Nevada. Simpson was not immediately arrested and was later released. He was not a guest at the hotel.

Las Vegas Metropolitan Police (LVMPD) began to question Simpson and at least five other people, after they were accused of breaking into a room in the hotel, with at least one of the individuals holding a gun, but its not known if the room was a guest room.

Several sports memorabilia items, all previously belonging to Simpson, were reported to be stolen from the room, which was registered to sports memorabilia collector Alfred Beardsley, and reports say that when police found the items, Simpson claimed that they belonged to him. Among the items stolen is believed to be a suit that Simpson wore during his 1995 murder trial, an autographed item that had been signed by Joe Montana, and “never before released” version of Simpson’s book If I Did It. Simpson was found not guilty of the murders of his ex-wife Nicole Brown Simpson and Ronald Goldman.

“When they talked to him, Simpson made the comment that he believed the memorabilia was his. We’re getting conflicting stories from the two sides,” said Jose Montoya, a spokesman for the LVMPD.

Reports say that Beardsley was going to sell the items and made plans to meet with someone on Thursday night who was interested in purchasing them. The unnamed individual, along with OJ claimed to be police officers and ordered Beardsley to turn over his cellular phone, which he refused. He then claims one of the men “roughed him up” before stealing every collectible in the room.

Police are expected to release a statement to the media later today.

Wednesday, June 12, 2013

In May, periodical cicadas with 17 years life cycle emerged on the East Coast of the USA after underground development as juveniles since 1996. Researchers and scientists worked to map and study the rare wave, and the locals prepared for the noisy event. First recorded in 1666, the Magicicada septendecim species recently emerged in 1979, 1996, this year, with a next wave due in 2030.

This week, Wikinews interviewed Chris Simon, an ecology and evolutionary biologist at University of Connecticut, about the cicadas.

((Wikinews)) What caused your initial interest in periodical cicadas?

Chris Simon: As an undergraduate student, I was interested in the formation of species so when I went to graduate school I looked for a study organism that was likely to be in the process of forming new species. I chose periodical cicadas because they are broken up into reproductively isolated broods (or year classes). Reproductive isolation leads to speciation so I planned to study biochemical differences among the broods.

((WN)) You study the emergence of the periodical cicadas. What do you study? What observations are you making?

CS: We record exactly where each cicada population emerges (using GPS automated mapping and crowd sourcing). We record the presence or absence of each of the three morphologically distinct species groups of periodical cicadas (Decim group, Cassini group, and Decula group). We collect specimens for DNA analysis. We look for cicadas coming up one and four years early and late. We dig up cicada nymphs and monitor their growth rates.

((WN)) What equipment do you use?

CS: Nets, shovels, automated GPS recorders, cameras, laptop computers, automated DNA sequencers.

((WN)) Do you study the periodical cicadas with anyone else? What is their role?

CS: Yes, there are a large number of people studying periodical cicadas in my lab and in other labs. My lab is made up of Research Scientists, Postdoctoral Researchers, a technician, graduate students, and undergraduates. Research Scientist John Cooley is the leader of the GPS mapping project; he invented the automated GPS recorder; he built our crowd-sourcing website, and he is instrumental in public outreach. Postdoctoral research David Marshall also participates in the mapping project and leads the part of the research related to the mapping of stragglers. John and Dave and Technician Kathy Hill all study periodical cicada mating behavior and conduct mating and hybridization experiments. One of my graduate students Beth Wade has participated in the nymph collections and will soon start genetic work involving genome wide association mapping designed to locate genes related to life cycle. My graduate student Russ Meister is studying the genes of the bacterial endosymbionts of cicadas. My current undergraduate honors student Erin Dwyer is also studying the development of Magicicada nymphs and is helping to design a lab exercise for college students around the eastern US to do the same. Many of my past undergraduate students have studied the biochemical genetics and development of periodical cicadas. See the Simon Lab website.

CS: We are collaborating with Teiji Sota at the University Kyoto and Jin Yoshimura at Shizuoka University in Japan. They are studying the phylogeography of Magicicada. We are collaborating with John McCutcheon of the University of Montana who is studying the endosymbiont genomes.

CS: We are also collaborating with ecologists Rick Karban and Louie Yang, both professors at UC Davis who have an interest in cicada population dynamics and nutrient cycling in the ecosystem.

((WN)) You studied the periodical cicadas in 1979 and 1996 too. What changes with time?

CS: I have studied periodical cicadas since I was a student back in 1974. What changes with time is increased human development constantly shrinking the patch size of cicada populations.

((WN)) What are your thoughts on the long life span of the periodical cicadas? Why could it be so? What advantages and what disadvantages does it have?

CS: Most or all cicadas have long life cycles compared to your typical annual insect. Examples have been found of two-year to 9-year cycles in different species. Periodical cicadas evolved an even-longer life cycle and I think that part of this relates to the evolution of their synchronized life cycles and peculiar safety-in-numbers strategy for survival. To become synchronized, periodical cicadas had to evolve an exact length life cycle and all adults would have to appear in the same year. Because the nymphs grow at different rates underground, a longer life cycle and a way of counting years must have evolved so that the individuals that get to the last nymphal (underground juvenile) stage first would wait long enough for all other individuals in the population to become ready to emerge.

((WN)) News reports mention this is ‘Brood II’ of the periodical cicadas. What are the distinctive features of this specific species and what is its full scientific name?

CS: The same species exist in multiple broods. No species is restricted to Brood II. The three species present in Brood II are: Magicicada septendecim, M. cassini, and M. septendecula. These same three species are found in every 17-year brood (except the farthest north which only has M. septendecim).

((WN)) At what depth do the cicadas juveniles live underground?

CS: Most live within the top foot of soil but some have been found deeper. We do not know if they go deeper in winter. We need to do much more digging to understand the nymphs.

((WN)) How do people prepare for the cicada emergence?

CS: Of course various people prepare in different ways. Ideally, everyone prepares by studying information available on the web (especially on our websites Magicicada Central and Magicicada.org).

((WN)) Do cicadas affect transport in the local area?

CS: No, not really. Occasionally individuals can be seeing flying across highways and sometimes they smash into cars.

((WN)) Do cicadas usually stay outside or do they also invade houses too?

CS: They stay outside. One might accidentally fly in through an open window but that would be rare.

((WN)) What do the cicadas eat?

CS: Cicadas suck xylem fluid (the watery fluid coming up from the roots of plants) in deciduous forest trees and herbs. Essential amino acids in the cicada diet are supplied by their bacterial endosymbionts. There are two species of endosymbionts. One makes 8 essential amino acids and one makes two essential amino acids.

((WN)) Do cicadas damage crops or city vegetation? What damage?

CS: Cicadas do not chew leave so they do not damage crops like other insects. They can inflict some damage by their egg laying. Cicadas lay eggs in pencil-sized tree branches. If there are not enough branches available, too many female cicadas may lay eggs in a single branch weakening it and making it susceptible to breakage by wind. This can sometimes cause damage in fruit orchards. If the branches break, the eggs die so this behavior is selected against by natural selection.

((WN)) Thank you.

CS: You’re welcome. I am happy to have this opportunity to communicate with your readers!

Wednesday, January 28, 2009

The British government has announced a £2.3 billion package of aid to attempt to support the country’s car manufacturing industry.

Lord Peter Mandelson, the Secretary of State for Business, Enterprise and Regulatory Reform announced to the House of Lords that the government planned to obtain £1.3 billion from the European Investment Bank for the industry. A further £1 billion loan is available if the industry agrees to invest it in environmentally friendly vehicles.

Mandleson told the Lords that the industry is vital to the British economy, which with “near one million employees from manufacturing to retailing” provides “£10 billion worth of added value to the economy.” However, he stressed that the government was not providing a “blank cheque” and would not provide operating subsidies.

His newly-appointed shadow Kenneth Clarke told the House of Commons that the plans were “pretty small beer” and repeated the Conservative charge that the government was “dithering” in the face of the downturn. Liberal Democrat John Thurso also expressed disappointment in the plans.